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44 TOWNSEND LETTER – NOVEMBER 2010 This report synthesizes three decades of investigations into the determinants of healthy and unhealthy immune defenses and repair responses. The function of immune defenses and repair systems (IDRS) in good and in ill health are compared and contrasted. 1 An integrative approach to interdependent neuroimmunohormonal, digestive, and detoxification systems is included. The Alkaline Way is a three- component approach that can be useful in addressing autoimmune and immune dysfunction conditions such as fibromyalgia and chronic fatigue syndrome, through an individualized approach that includes: • lab testing for inflammation, detoxification, and antigens to food and chemicals; • an alkaline diet including supplements and self-testing to monitor pH levels; • lifestyle management – with an emphasis on exercise and mindfulness. The program described has achieved impressive rates of remission, demonstrating how forgiving and responsive the human body can be when biochemistry is restored to balance. Better outcomes are achieved by concurrently applying three interventions that reaffirm the body's inherent healing abilities by removing obstacles to recovery. An Epidemic of Epidemics of Autoimmune Diseases More than half of all American adults and a rapidly growing proportion of young people experience some type of autoimmune condition. Within the body, this reflects a shift from an immune system that is resilient, self-regulating, and self-restoring into an imbalanced, aggressive, and self-attacking mode known as autoimmunity (AI). 2 There is considerable diagnostic overlap of AI with chronic and degenerative diseases. 3 It is increasingly clear that most heart disease and chronic vascular conditions are the result of loss of repair ability due to excess cell acid (metabolic acidosis) and oxidative stress due to deficits in essential antioxidant and buffering nutrients that cause losses of tolerance in the immune defense and deferred repair (IDRS dysfunction). 4 Case examples and outcome studies in fibromyalgia muscle pain, chronic fatigue immune dysfunction syndrome (CFIDS), and other autoimmune conditions have been previously reported. 1 Acidosis, oxidative stress, and in- flammation – Metabolic acidosis, oxi- dative stress-makers, and repair deficit inflammation are the antecedents of autoimmune and immune dysfunc- tion which functionally and metaboli- cally overlap with debilitating chronic conditions that affect or are affected by the thyroid, adrenals, or reproduc- tive glands (See Figure 1, p. 47; Table 1). 5-8 The Alkaline Way Program The Alkaline Way plan described here assesses an individual's metabolic balance. Sustained remission routinely emerges when these approaches are consistently applied. 9 1. Laboratory Tests: Assess Causes More Than Pathologic Consequences Inflammation, Detoxification, and Immune Function In ill health, tolerance and homeostatic resilience are reduced and in some cases lost. 10 AI and immune dysfunction occur commonly, and commonly together. 11 They reflect the impairment or loss of immune defenses and repair tolerance and competences. A Health Studies Collegium estimate is that loss of tolerance and homeostasis accounts for one- third of all chronic disease. These are the inflammatory conditions, the conditions of cumulative repair deficit that reduce life quality and increase costs of mostly palliative care. Inflammatory markers of repair deficit include elevations of: • sedimentation rate (sed rate) • unexplained elevation of fibrinogen, ferritin, and microalbumin, among other inducible proteins • C-reactive protein (hsCRP) • tumor necrosis factor (TNF) • oxidative stress markers such as oxidized LDL/HDL and 8-oxo- guanine • prealbumin in urine • IL-2, IL-6, and IL-12, among other cytokines The Alkaline Way: Integrative Management of Autoimmune Conditions by Russell Jaffe

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